The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer

The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer

Blog Article

Lung cancer: Targeting a vicious circle Therapies targeting a molecular feedback loop involved in tumor growth may prove valuable for treating non-small-cell lung cancer.Fangbao Ding, Jianbing Huang, and co-workers at Shanghai Jiao Tong University in Shanghai, China, have shown how an enzyme called USP21 promotes cancer cell proliferation and tumor growth in non-small-cell lung cancer.The team telemarkskongen flue took cancerous and non-cancerous lung tissue samples from 42 patients, and analyzed the expression and read more behavior of USP21.The enzyme was highly expressed in cancerous tissues, where it stabilized a known gene with the potential to cause cancer called YY1.This gene also regulated the expression of a particular RNA molecule, which in turn worked to increase levels of USP21.

This cyclical process encouraged the proliferation, migration and invasion of non-small-cell lung cancer cells, and may provide a future therapeutic target.